Research Fellow

The Lee Kong Chian School of Medicine (LKCMedicine) trains

doctors who put patients at the centre of their exemplary care. The

School, which offers both undergraduate and graduate programmes, is

named after local philanthropist Tan Sri Dato Lee Kong Chian.

Established in 2010 by Nanyang Technological University, Singapore,

in partnership with Imperial College London, LKCMedicine aims to be

a model for innovative medical education and a centre for

transformative research. The School's primary clinical partner is

the National Healthcare Group, a leader in public healthcare

recognised for the quality of its medical expertise, facilities and

teaching. The School is transitioning to an NTU medical school

ahead of the 2028 successful conclusion of the NTU-Imperial

partnership to set up a Joint Medical School. In August 2024, we

welcomed our first intake of the NTU MBBS programme, that has been

recently enhanced to include themes like precision medicine and

Artificial Intelligence (AI) in healthcare, with an expanded scope

in the medical humanities. Graduates from the five-year

undergraduate medical degree programme will have a strong

understanding of the scientific basis of medicine, with an emphasis

on technology, data science and the

humanities.

The Molecular and Cellular

Dysfunction in Diabetes Laboratory, led by Associate Professor

Yusuf Ali, combines in vitro systems biology, advanced imaging, in

vivo models and multi-omics technologies to elucidate pathways

critical to type 2 diabetes mellitus pathogenesis, with focus on

pancreatic and immune function. The team is moving into molecular

nutrition, harnessing the power of novel ingredients and prebiotics

to mitigate the rise of persons living with diabetes. A laboratory

under the Nutrition, Metabolism and Health programme, our work

seeks for causality so that we can translate mechanistic insights

into therapeutic strategies for mitigating type 2 diabetes and

related metabolic conditions.

For more details,

please view :

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https : / / dr.ntu.edu.sg / cris / rp / rp00609

We

are seeking a passionate and motivated Research Fellow to

contribute to a high-impact project exploring how intracellular

lipid regulation is altered under different diets and how the

endocrine pancreas can be better protected under obesity and

metabolically dysregulated conditions. As type 2 diabetes is also a

condition of low grade chronic inflammation, expertise on studying

how circulating immune cells interact with tissue-specific immune

cells will be a plus. The project investigates molecular mechanisms

underpinning cell stress and resilience, integrating in vitro and

in vivo studies using genetically modified mouse models, human

islets, and multi-omics approaches. This position is ideal for

researchers with a strong interest in lipid metabolism,

autophagy / lipophagy, and diabetes

pathophysiology.

Key

Responsibilities : Conduct various in

vitro assays / experiments, including histology, western blotting,

immunofluorescence microscopy, etc.

Perform in

vivo experiments, animal studies

Computational

biology to integrate results and generate list of perturbed

pathways

Contribute to research grant proposal

applications, including literature review and preliminary

data

Contribute to research deliverables, such

as manuscript writing, attending local and / or international

conferences

Mentor and supervision of

undergraduate / PhD students and junior research staff

Collaborate effectively with the research teams to

achieve overall research goals and

objectives

Required educational

qualification, experience, skills and

competencies :

PhD in Life Sciences,

Biomedical Sciences, or related field

At least

2-3 years of relevant experience in molecular biology, cell

culture, imaging, or metabolic disease models

Strong technical proficiency in laboratory techniques

such as immunoblotting, immunofluorescence microscopy, qPCR, and

animal handling

Familiarity with regulatory

standards, good laboratory practices and experience with IACUC

protocols

Excellent written and oral

communication skills, with demonstrated ability to draft scientific

manuscripts and presentations

Strong

organizational, motivational and self-driven skills, with a

team-plater attitude

(Entry-level candidates

with strong experimental skills and interest in metabolic disease

research are welcome to apply)